There is a launch of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors within the dorsal horn to lower afferent pain transmission and generate analgesia. Hence, medicine like clonidine that concentrate on alpha-2 receptors can affect the transmission of pain. Relates to clonidine: oral pill, oral https://webookmarks.com/story5325178/onolidine-an-overview