There exists a launch of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to minimize afferent pain transmission and develop analgesia. Thus, medicine like clonidine that focus on alpha-2 receptors can influence the transmission of agony. Clonidine is dispersed in breast milk; https://www.proleviate.com/post/the-new-pain-killer-conolidine