Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts through the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have discovered recurrent mutations in genes regulating tumor mobile-microenvironment inte... https://shirinl899skd2.humor-blog.com/profile