Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts through the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have determined recurrent mutations in genes regulating tumor cell-microenvironment interactions... https://kedarc107bkt5.buyoutblog.com/profile